National Institute of Genetics 国立遺伝学研究所 木村暁研究室

RESEARCH ARTICLES


Kondo, T. and Kimura, A. (2018). Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles. bioRxiv doi: 10.1101/450478. (October 23, 2018)

Kondo, T., and A. Kimura. 2018. Impaired chromosome segregation results in sperms with excess centrosomes in emb-27APC6 mutant C. elegans. bioRxiv doi: 10.1101/449538 (October 22, 2018)

Kikuchi Y., *Kimura A. Microinjection into the Caenorhabditis elegans embryo using an uncoated glass needle enables cell lineage visualization and reveals cell-non-autonomous adhesion control. bioRxiv doi: 10.1101/406991 (September 3, 2018)

Ohta M, Watanabe K, Ashikawa T, Nozaki Y, Yoshiba S, Kimura A, *Kitagawa D. Bimodal binding of STIL to Plk4 controls proper centriole copy number. Cell Reports 23, 3160-3169.e4. (2018) doi: 10.1016/j.celrep.2018.05.030.

Sugioka K, Fielmich L-E, Mizumoto K, Bowerman B, van den Heuvel S, Kimura A, *Sawa H. The tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division. Proc Natl Acad Sci USA 115, E954-E963 (2018). doi: 10.1073/pnas.1712052115 (January 18, 2018)

Yamamoto K, *Kimura A. An anisotropic attraction model for the diversity and robustness of cell arrangement in nematodes. Development, 144, 4437-4449 (2017). doi: 10.1242/dev.154609
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Arai R, Sugawara T, Sato Y, Minakuchi Y, Toyoda A, Nabeshima K, Kimura H, *Kimura A. Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans. Scientific Reports, 7, 3631 (2017). doi:10.1038/s41598-017-03483-5 (June 16, 2017)

Hara Y, Adachi K, Kagohashi S, Yamagata K, Tanabe H, Kikuchi S, Okumura S-I, *Kimura A. Scaling relationship between intra-nuclear DNA density and chromosomal condensation in metazoan and plant. Chromosome Science, 19, 43-49 (2016). doi:10.11352/scr.19.43 (Released: June 26, 2017)

Kimura K., Mamane A., Sasaki T., Sato K., Takagi J., Niwayama R., Hufnagel L., Shimamoto Y., Joanny J.-F., Uchida S., *Kimura A. Endoplasmic Reticulum-Mediated Microtubule Alignment Governs Cytoplasmic Streaming. Nature Cell Biology, 19, 399-406. (2017) DOI: 10.1038/ncb3490 [PDF: SharedIt]


Sato Y., Kujirai T., Arai R., Asakawa H., Ohtsuki C., Horikoshi N., Yamagata K., Ueda J., Nagase T., Haraguchi T., Hiraoka Y., Kimura A., Kurumizaka H., *Kimura, H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J. Mol. Biol. 428, 3885-3902 (2016). doi: 10.1016/j.jmb.2016.08.010

Niwayama R., Nagao H., Kitajima T. S., Hufnagel L., Shinohara K., Higuchi T., Ishikawa T., *Kimura A. Bayesian Inference of Forces Causing Cytoplasmic Streaming in Caenorhabditis elegans Embryos and Mouse Oocytes. PLoS ONE 11, e0159917 (2016). doi: 10.1371/journal.pone.0159917

*Matsumura S., Kojidani T., Kamioka Y., Uchida S., Haraguchi T., Kimura A., and Toyoshima F. Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1. Nature Communications 7, 11858 (2016)

Tanimoto H., *Kimura A., *Minc N. Shape-motion relationships of centering microtubule asters. J. Cell Biol. 212, 777-787 (2016). doi: 10.1083/jcb.201510064

Nakaoka Y, Kimura A, Tani T, *Goshima G. Cytoplasmic nucleation and atypical branching nucleation generate endoplasmic microtubules in Physcomitrella patens. Plant Cell 27, 228-242 (2015)

Hara Y, Iwabuchi M, Ohsumi K, *Kimura A._Intranuclear DNA density affects chromosome condensation in metazoans. Mol Biol. Cell 24, 2442–2453 (2013).

Hara Y, *Kimura A._An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos. Mol Biol. Cell 24, 1411-1419 (2013).

Kimura K., and *Kimura A._Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans. J. Cell Sci. 125, 5897-5905 (2012).

Okubo Y., Sugawara T., Abe-Koduka N., Kanno J., *Kimura A., *Saga Y._Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signaling. Nat. Comm. 3, 1141 (2012).

Hayashi H., Kimura K., and *Kimura A._Localized accumulation of tubulin during semi-open mitosis in the Caenorhabditis elegans embryo. Molecular Biology Cell 23, 1688-1699 (2012).

Koyama H., Umeda T., Nakamura K, Higuchi T. and *Kimura A._A high-resolution shape fitting and simulation demonstrated equatorial cell surface softening during cytokinesis and its promotive role in cytokinesis. PloS ONE 7, e31607 (2012).

Niwayama R., Shinohara K., and *Kimura A. The hydrodynamic property of the cytoplasm is sufficient to mediate cytoplasmic streaming in the Caenorhabiditis elegans embryo. Proc. Natl. Acad. Sci. USA, 108, 11900-11905 (2011).

Aoki, K., Hayashi, H., Furuya, K., Sato, M., Takagi, T., Osumi, M., Kimura, A., and *Niki, H. Breakage of the nuclear envelope by an extending mitotic nucleus occurs during anaphase in Schizosaccharomyces japonicus. Genes to Cells, 16, 911-926 (2011).

*Kosodo Y., Suetsugu T., Suda M., Mimori-Kiyosue Y., Toida K., Baba S.A., Kimura A., *Matsuzaki F. Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain. EMBO J. 30, 1690-1704 (2011).

Kimura K., and *Kimura A. Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. Proc. Natl. Acad. Sci. USA 108, 137-142 (2011).

Oginuma M., Takahashi Y., Kitajima S., Kiso M., Kanno J., Kimura A., and *Saga Y. The oscillation of Notch activation but not its boundary is required for somite border formation and rostral-caudal patterning within a somite. Development, 137, 1515-1522 (2010).

Hara Y., *Kimura A.  Cell-size-dependent spindle elongation in the Caenorhabditis elegans early embryo. Curr Biol. 19, 1549-1554 (2009). *論文の表紙に採用されました*

Invited Publication/Review Articles


Sugawara T, *Kimura A. Physical properties of the chromosomes and implications for development. (Review) Development, Growth, and Differentiation, 59, 405-414 (2017). doi: 10.1111/dgd.12363. (Jun 2, 2017)

*Kimura A, Celani A, Nagao H, Stasevich T, Nakamura K. Estimating cellular parameters through optimization procedures: elementary principles and applications. Frontiers in Physiology 6, 60. doi: 10.3389/fphys.2015.00060 (2015)

*Marshall M.F., Young K.D., Swaffer M., Wood E., Nurse P., Kimura A., Frankel J., Wallingford J., Walbot V., Qu X., and Roeder A.H.K. What determines cell size? BMC Biology 10, 101 (2012).

Kimura K., *Kimura A. A novel mechanism of microtubule length-dependent force to pull centrosomes toward the cell center. BioArchitecture 1, 74-79 (2011) DOI: 10.4161/bioa.1.2.15549

Kimura A., *Onami S. Modeling microtubule-mediated forces and centrosome positioning in Caenorhabditis elegans embryos. Methods in Cell Biology 97, 437-453 (2010)

*Goshima G., *Kimura A. New look inside the spindle: microtubule-dependent microtubule generation within the spindle. Curr Opin Cell Biol 22, 44-49 (2009)

Book Chapter

Hara Y., *Kimura, A. Cell-size-dependent control of organelle sizes during development. In “Cell Cycle in Development” (Kubiak JZ Ed.) Springer Series: Results and Problems in Cell Differentiation 53, 93-108 (2011)

Publication in Japanese


木村暁「建築家のいない建築はどのようにできるのか? – 細胞質流動の研究から「隠れた秩序」に迫る」academist journal, August 2, 2017 < https://academist-cf.com/journal/?p=5455 >

木村健二, 高木潤, 庭山律哉, 島本勇太, 内田誠一, 木村暁. 細胞質流動が自発的に流れの方向をそろえるしくみ, 逆転させるしくみ 実験医学 35 (13), 2250-2253. (August 1, 2017)

木村健二, 木村暁.細胞質流動の発生および逆転は小胞体のネットワークにより支配される. ライフサイエンス新着論文レビュー. (2017) 10.7875/first.author.2017.029 (April 3, 2017)

木村暁「DNA-多様性を生み出す生命の設計図」Re (建築保全センター発行) 193, 14-19 (January 1, 2017)

谷本博一, 木村健二, 木村暁. 核はどのようにして細胞の中心を見つけるのか?生物物理 Vol 327 (56-5) (2016).

木村健二, *木村暁 「細胞分裂の力学的理解」 細胞工学 32, 280-284 (2013).

木村暁 「細胞サイズの定量生物学」生化学82 (4), 302-305 (2010)

木村暁 「細胞核の大きさと場所はどのように決まるのか」実験医学(増刊)27(17), 2779-2786 (2009)

木村暁 「Book Review: 生命の数理(巌佐庸著)」蛋白質核酸酵素 53, 1307 (2008)

2009年の論文が表紙に採用されました。